By addressing a long-standing open problem, listed in a highly regarded collection of open questions in the field and described as a "worthwhile research project", this note extends Markov's theorem (Markoff, Math. Ann., 27:177-182, 1886) on the variation of zeros of orthogonal polynomials on the real line to the setting of multiple orthogonal polynomials on Angelesco sets. The analysis reveals that the only distinction from the classical 1886 result lies in establishing sufficient conditions for a given Z-matrix-which, in the Markov case, is the identity matrix-to be an M-matrix. In contrast to most existing studies, which often present highly technical proofs for specific results, this note seeks to provide a simple proof of a general result without imposing restrictions on the weight functions (such as their potential "classical" nature), the number of intervals, or the structure of the partition.